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This was for Credit level only. The myeloid HL leukemia cell line also underwent apoptosis by treatments that reduce c-MYC expression [ 49 ]. By continuing to use this site, you are consenting to our use of cookies. Zhang W, Liu HT. Reflecting on 25 years with MYC. Assessment of cell death by flow cytometry The cell death mode induced by shikonin and its derivatives was analyzed by annexin V-PI double staining. These pathways play an important role in the control of c-MYC protein stability, accumulation and subsequent transcriptional activity.


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Reduced expression of MYC increases longevity and enhances healthspan. Abstract Leukemia remains life-threatening despite remarkable advances in chemotherapy. Cold Spring Harbor perspectives in medicine.

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